Mou Nyee has a rich and varied work experience. He started his career at a family service center, where he worked primarily with youths and parents, provided counseling services for secondary schools and young "delinquents". He also worked extensively with distressed families and couples referred by the Family Court. In addition, he also has experience working with people with disabilities, elderly and their caregivers, and university students with relationship and mental health challenges. Mou Nyee also has many years of experience leading and facilitating group programs. 

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Apart from counselling and group work, Mou Nyee also has experience providing Employee Assistance Programs (EAP) services for corporate companies and provides training and talks to corporations. He also is an adjunct lecturer for various institutions providing counselling related training.